PME-1 is regulated by USP36 in ERK and Akt signaling pathways.
FEBS Lett
; 592(9): 1575-1588, 2018 05.
Article
em En
| MEDLINE
| ID: mdl-29577269
ABSTRACT
Deubiquitinating enzymes (DUBs) play an important role in the ubiquitin-proteasome system (UPS) by eliminating ubiquitins from substrates and inhibiting proteasomal degradation. Protein phosphatase methylesterase 1 (PME-1) inactivates protein phosphatase 2A (PP2A) and enhances the ERK and Akt signaling pathways, which increase cell proliferation and malignant cell transformation. In this study, we demonstrate that USP36 regulates PME-1 through its deubiquitinating enzyme activity. USP36 increases PME-1 stability, and depletion of USP36 decreases the PME-1 expression level. Furthermore, we demonstrate that USP36 promotes the ERK and Akt signaling pathways. In summary, it is suggested that USP36 regulates PME-1 as a DUB and participates in the ERK and Akt signaling pathways.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Hidrolases de Éster Carboxílico
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Transdução de Sinais
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Ubiquitina Tiolesterase
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MAP Quinases Reguladas por Sinal Extracelular
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Proteínas Proto-Oncogênicas c-akt
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article