Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3ß and NF-&#954;B Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection.

Chen, Chia-Ling; Cheng, Miao-Huei; Kuo, Chih-Feng; Cheng, Yi-Lin; Li, Ming-Han; Chang, Chih-Peng; Wu, Jiunn-Jong; Anderson, Robert; Wang, Shuying; Tsai, Pei-Jane; Liu, Ching-Chuan; Lin, Yee-Shin

Dextromethorphan Attenuates NADPH Oxidase-Regulated Glycogen Synthase Kinase 3ß and NF-κB Activation and Reduces Nitric Oxide Production in Group A Streptococcal Infection.

Chen, Chia-Ling; Cheng, Miao-Huei; Kuo, Chih-Feng; Cheng, Yi-Lin; Li, Ming-Han; Chang, Chih-Peng; Wu, Jiunn-Jong; Anderson, Robert; Wang, Shuying; Tsai, Pei-Jane; Liu, Ching-Chuan; Lin, Yee-Shin.

Afiliação

Chen CL; School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei, Taiwan.
Cheng MH; Department of Nursing, I-Shou University, Kaohsiung, Taiwan.
Kuo CF; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Cheng YL; Department of Nursing, I-Shou University, Kaohsiung, Taiwan.
Li MH; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chang CP; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wu JJ; Department of Microbiology and Immunology, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Anderson R; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Wang S; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Tsai PJ; Department of Biotechnology and Laboratory Science in Medicine, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan.
Liu CC; Center of Infectious Disease and Signaling Research, National Cheng Kung University, Tainan, Taiwan.
Lin YS; Departments of Microbiology & Immunology and Pediatrics, and Canadian Center for Vaccinology, Dalhousie University, Halifax, Canada.

Antimicrob Agents Chemother ; 62(6)2018 06.

Article em En | MEDLINE | ID: mdl-29581121

Assuntos

Dextrometorfano/uso terapêutico; Óxido Nítrico Sintase Tipo II/metabolismo; Infecções Estreptocócicas/tratamento farmacológico; Infecções Estreptocócicas/enzimologia; Animais; Quinase 3 da Glicogênio Sintase/genética; Quinase 3 da Glicogênio Sintase/metabolismo; Humanos; Inflamação/metabolismo; Camundongos; Camundongos Endogâmicos BALB C; NF-kappa B/metabolismo; Óxido Nítrico Sintase Tipo II/genética; Oniocompostos/farmacologia; Oxirredução/efeitos dos fármacos; Fosforilação/efeitos dos fármacos; Fosforilação/genética; Células RAW 264.7; Espécies Reativas de Oxigênio/metabolismo; Transdução de Sinais/efeitos dos fármacos; Transdução de Sinais/genética; Infecções Estreptocócicas/metabolismo; Células THP-1

Palavras-chave

dextromethorphan; group A Streptococcus; inflammation

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infecções Estreptocócicas / Dextrometorfano / Óxido Nítrico Sintase Tipo II Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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