Absence of 1p/19q codeletion in oligodendroglioma-like areas of pilocytic astrocytomas.
Clin Neuropathol
; 37(4): 182-185, 2018.
Article
em En
| MEDLINE
| ID: mdl-29595124
ABSTRACT
The presence of oligodendroglioma-like areas in pilocytic astrocytoma may give rise to pathologic diagnostic uncertainty. This study aims to determine if the oligodendroglioma-like areas present in some pilocytic astrocytomas (PA) possess the signature 1p/19q codeletion that is characteristic of classical oligodendroglioma. Array comparative genomic hybridization was carried out on 12 PA samples, from which oligodendroglioma-like areas were microdissected and used as the template DNA source. 1p/19q codeletions were not found in any of the oligodendroglioma areas in PAs. We conclude that PAs with oligodendroglioma-like areas do not share the same molecular genetics as classic oligodendroglioma.â©.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Oligodendroglioma
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Astrocitoma
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Cromossomos Humanos Par 1
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Cromossomos Humanos Par 19
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Deleção Cromossômica
Limite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article