[Absorption of Inula cappa extract based on everted intestinal sac method].
Zhongguo Zhong Yao Za Zhi
; 43(3): 609-617, 2018 Feb.
Article
em Zh
| MEDLINE
| ID: mdl-29600630
ABSTRACT
To investigate the absorptive characteristics of Inula cappa extract based on the rat everted intestinal sac method in vitro. Nine representative ingredients in I. cappa extract were selected as the study objects. An UPLC-MS/MS method was established to determine and detect their cumulative absorption amount for expounding the absorptive characteristics of ingredients in different intestinal sections. According to the resultsï¼ the transport mechanism of 8 compounds showed passive diffusion by the reverted gut sac method. And scopolin was actively transported in the intestine. The best absorption site of chlorogenic acid was duodenum. The best absorption site of cryptochlorogenic acidï¼ 1ï¼3-O-dicaffeoylquinic acidï¼ luteolin-7-glucoside and 3ï¼4-O-dicaffeoylquinic acid were jejunum. The best absorption site of neochlorogenic acidï¼ scopolinï¼ 4ï¼5-O-dicaffeoylquinic acid and 3ï¼5-O-dicaffeoylquinic acid was ileum. The absorption of all the compounds was affected by pH and bile. All of the nine ingredients in I. cappa extract could be absorbed in intestinesï¼ but with differences in the absorption rateï¼ the best absorptive site and mechanismï¼ indicating that the intestinal absorption of I. cappa extract was selective.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
/
Inula
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Absorção Intestinal
/
Intestinos
Limite:
Animals
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article