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Lead Diversification at the Nanomole Scale Using Liver Microsomes and Quantitative Nuclear Magnetic Resonance Spectroscopy: Application to Phosphodiesterase 2 Inhibitors.
Obach, R Scott; Walker, Gregory S; Sharma, Raman; Jenkinson, Stephen; Tran, Tuan P; Stepan, Antonia F.
Afiliação
  • Obach RS; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Walker GS; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Sharma R; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Jenkinson S; Pfizer Worldwide Research and Development , 10770 Science Center Drive , La Jolla , California 92121 , United States.
  • Tran TP; Pfizer Worldwide Research and Development , Eastern Point Road , Groton , Connecticut 06340 , United States.
  • Stepan AF; Pfizer Worldwide Research and Development , 610 Main Street , Cambridge , Massachusetts 02139 , United States.
J Med Chem ; 61(8): 3626-3640, 2018 04 26.
Article em En | MEDLINE | ID: mdl-29601185
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Microssomos Hepáticos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Inibidores de Fosfodiesterase / Microssomos Hepáticos / Nucleotídeo Cíclico Fosfodiesterase do Tipo 2 Limite: Animals / Female / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article