Taking a position on intramembrane proteolysis.
J Biol Chem
; 293(13): 4664-4665, 2018 03 30.
Article
em En
| MEDLINE
| ID: mdl-29602877
ABSTRACT
Decades of work have contributed to our in-depth mechanistic understanding of soluble proteases, but much less is known about the catalytic mechanism of intramembrane proteolysis due to inherent difficulties in both preparing and analyzing integral membrane enzymes and transmembrane substrates. New work from Naing et al. tackles this challenge by examining the catalytic parameters of an aspartyl intramembrane protease homologous to the enzyme that cleaves amyloid precursor protein, finding that both chemistry and register contribute to specificity in substrate cleavage.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Membrana Celular
/
Ácido Aspártico Proteases
/
Proteólise
/
Amiloide
/
Proteínas de Membrana
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article