Synthesis and antiproliferative activity of new mycophenolic acid conjugates with adenosine derivatives.
J Asian Nat Prod Res
; 21(2): 178-185, 2019 Feb.
Article
em En
| MEDLINE
| ID: mdl-29607657
ABSTRACT
New conjugates of mycophenolic acid (MPA) and adenosine derivatives were synthesized and assessed as potential immunosuppressants on Jurkat cell line and peripheral blood mononuclear cells (PBMC) from healthy donors. As compared to MPA, all compounds were found to be more active against Jurkat cell line. The antiproliferative activities were compared with MPA and adenosine, in both 2',3'-O-isopropylidene protected and free hydroxyl groups possessing forms. The obtained results were also discussed in terms of selectivity index, defined as SI = IC50/EC50.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Adenosina
/
Imunossupressores
/
Ácido Micofenólico
Limite:
Humans
Idioma:
En
Ano de publicação:
2019
Tipo de documento:
Article