Nitrate-promoted Selective C-H Fluorination of Benzamides and Benzeneacetamides.
Org Lett
; 20(8): 2445-2448, 2018 04 20.
Article
em En
| MEDLINE
| ID: mdl-29634276
ABSTRACT
A versatile and site-selective nitrate-promoted C-H bond fluorination using various weak coordinating amides as intrinsic directing groups was developed. Diverse tertiary and secondary amides underwent selective aromatic C-H bond fluorination, which features broad substrate scope, good regioselectivity, and mild conditions. Moreover, the late-stage C-H bond fluorination of the challenging benzeneacetamides via distal directing was reported for the first time.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article