HDAC3 inhibition in diabetic mice may activate Nrf2 preventing diabetes-induced liver damage and FGF21 synthesis and secretion leading to aortic protection.

Zhang, Jian; Xu, Zheng; Gu, Junlian; Jiang, Saizhi; Liu, Quan; Zheng, Yang; Freedman, Jonathan H; Sun, Jian; Cai, Lu

Zhang, Jian; Xu, Zheng; Gu, Junlian; Jiang, Saizhi; Liu, Quan; Zheng, Yang; Freedman, Jonathan H; Sun, Jian; Cai, Lu.

Afiliação

Zhang J; Cardiovascular Center, the First Hospital of Jilin University , Changchun, Jilin , China.
Xu Z; Department of Pediatrics, Pediatric Research Institute, University of Louisville , Louisville, Kentucky.
Gu J; Cardiovascular Center, the First Hospital of Jilin University , Changchun, Jilin , China.
Jiang S; Department of Pediatrics, Pediatric Research Institute, University of Louisville , Louisville, Kentucky.
Liu Q; Department of Pediatrics, Pediatric Research Institute, University of Louisville , Louisville, Kentucky.
Zheng Y; Department of Pediatrics, the First Affiliated Hospital of Wenzhou Medical University , Wenzhou, Zhejiang , China.
Freedman JH; Cardiovascular Center, the First Hospital of Jilin University , Changchun, Jilin , China.
Sun J; Cardiovascular Center, the First Hospital of Jilin University , Changchun, Jilin , China.
Cai L; Department of Pharmacology and Toxicology, University of Louisville , Louisville, Kentucky.

Am J Physiol Endocrinol Metab ; 315(2): E150-E162, 2018 08 01.

Article em En | MEDLINE | ID: mdl-29634312

Assuntos

Aorta/efeitos dos fármacos; Cardiotônicos/farmacologia; Complicações do Diabetes/prevenção & controle; Diabetes Mellitus Tipo 1/metabolismo; Fatores de Crescimento de Fibroblastos/biossíntese; Inibidores de Histona Desacetilases/farmacologia; Histona Desacetilases/efeitos dos fármacos; Hepatopatias/prevenção & controle; Fator 2 Relacionado a NF-E2/metabolismo; Animais; Fibrose/patologia; Fibrose/prevenção & controle; Inflamação/patologia; Inflamação/prevenção & controle; Proteína 1 Associada a ECH Semelhante a Kelch/genética; Proteína 1 Associada a ECH Semelhante a Kelch/metabolismo; Hepatopatias/etiologia; Hepatopatias/patologia; Masculino; Camundongos; MicroRNAs/metabolismo

Palavras-chave

FGF21; HDAC 3 inhibitor; Keap1; Nrf2; atherosclerosis; miRNA200a; type 1 diabetes

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Aorta / Cardiotônicos / Complicações do Diabetes / Diabetes Mellitus Tipo 1 / Fator 2 Relacionado a NF-E2 / Inibidores de Histona Desacetilases / Fatores de Crescimento de Fibroblastos / Histona Desacetilases / Hepatopatias Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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