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Molecular Signatures of Regression of the Canine Transmissible Venereal Tumor.
Frampton, Dan; Schwenzer, Hagen; Marino, Gabriele; Butcher, Lee M; Pollara, Gabriele; Kriston-Vizi, Janos; Venturini, Cristina; Austin, Rachel; de Castro, Karina Ferreira; Ketteler, Robin; Chain, Benjamin; Goldstein, Richard A; Weiss, Robin A; Beck, Stephan; Fassati, Ariberto.
Afiliação
  • Frampton D; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Schwenzer H; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Marino G; Department of Veterinary Sciences, Polo Universitario dell'Annunziata, University of Messina, Messina 98168, Italy.
  • Butcher LM; Department of Cancer Biology, Cancer Institute, UCL, 72 Huntley Street, London WC1E 6BT, UK.
  • Pollara G; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Kriston-Vizi J; MRC Laboratory for Molecular Cell Biology, UCL, Gower Street, London WC1E 6BT, UK.
  • Venturini C; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Austin R; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • de Castro KF; Transmissible Cancer Group, Department of Veterinary Medicine, University of Cambridge, Madingley Road, Cambridge CB3 0ES, UK.
  • Ketteler R; MRC Laboratory for Molecular Cell Biology, UCL, Gower Street, London WC1E 6BT, UK.
  • Chain B; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Goldstein RA; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Weiss RA; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK.
  • Beck S; Department of Cancer Biology, Cancer Institute, UCL, 72 Huntley Street, London WC1E 6BT, UK.
  • Fassati A; Department of Infection, Division of Infection & Immunity, University College London (UCL), Cruciform Building, 90 Gower Street, London WC1E 6BT, UK. Electronic address: a.fassati@ucl.ac.uk.
Cancer Cell ; 33(4): 620-633.e6, 2018 04 09.
Article em En | MEDLINE | ID: mdl-29634949
The canine transmissible venereal tumor (CTVT) is a clonally transmissible cancer that regresses spontaneously or after treatment with vincristine, but we know little about the regression mechanisms. We performed global transcriptional, methylation, and functional pathway analyses on serial biopsies of vincristine-treated CTVTs and found that regression occurs in sequential steps; activation of the innate immune system and host epithelial tissue remodeling followed by immune infiltration of the tumor, arrest in the cell cycle, and repair of tissue damage. We identified CCL5 as a possible driver of CTVT regression. Changes in gene expression are associated with methylation changes at specific intragenic sites. Our results underscore the critical role of host innate immunity in triggering cancer regression.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Venéreos Veterinários / Vincristina / Perfilação da Expressão Gênica / Doenças do Cão / Redes Reguladoras de Genes Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Tumores Venéreos Veterinários / Vincristina / Perfilação da Expressão Gênica / Doenças do Cão / Redes Reguladoras de Genes Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article