Mechanism of pattern recognition receptors (PRRs) and host pathogen interplay in bovine mastitis.
Microb Pathog
; 120: 64-70, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29635052
ABSTRACT
Bacterial infection in the mammary gland parenchyma induces local and subsequently systemic inflammation that results in a complex disease. Mastitis in bovine is the result of various factors which function together. This review is aimed to analyze the factors involved in the pathogenesis of common bacterial species for bovine mastitis. The bacterial growth patterns, signaling pathway and the pathogen-associated molecular patterns (PAMPs) which activate immune responses is discussed. Clear differences in bacterial infection pattern are shown between bacterial species and illustrated TLRs, NLRs and RLGs molecular mechanism for the initiation of intramammary infection. The underlying reasons for the differences and the resulting host response are analyzed. Understandings of the mechanisms that activate and regulate these responses are central to the development of efficient anticipatory and treatment management. The knowledge of bovine mammary gland to common mastitis causing pathogens with possible immune mechanism could be a new conceptual understanding for the prospect of mastitis control program.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Bacterianas
/
Viroses
/
Receptores de Reconhecimento de Padrão
/
Interações Hospedeiro-Patógeno
/
Glândulas Mamárias Animais
/
Mastite Bovina
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article