Four-Dimensional Imaging of T Cells in Kidney Transplant Rejection.
J Am Soc Nephrol
; 29(6): 1596-1600, 2018 06.
Article
em En
| MEDLINE
| ID: mdl-29654214
Kidney transplantation is the treatment of choice for ESRD but is complicated by the response of the recipient's immune system to nonself histocompatibility antigens on the graft, resulting in rejection. Multiphoton intravital microscopy, referred to as four-dimensional imaging because it records dynamic events in three-dimensional tissue volumes, has emerged as a powerful tool to study immunologic processes in living animals. Here, we will review advances in understanding the complex mechanisms of T cell-mediated rejection made possible by four-dimensional imaging of mouse renal allografts. We will summarize recent data showing that activated (effector) T cell migration to the graft is driven by cognate antigen presented by dendritic cells that surround and penetrate peritubular capillaries, and that T cell-dendritic cell interactions persist in the graft over time, maintaining the immune response in the tissue.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Linfócitos T
/
Microscopia de Fluorescência por Excitação Multifotônica
/
Microscopia Intravital
/
Rejeição de Enxerto
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article