Development of a Ga-68 labeled PET tracer with short linker for prostate-specific membrane antigen (PSMA) targeting.

Moon, Sung-Hyun; Hong, Mee Kyung; Kim, Young Ju; Lee, Yun-Sang; Lee, Dong Soo; Chung, June-Key; Jeong, Jae Min

Moon, Sung-Hyun; Hong, Mee Kyung; Kim, Young Ju; Lee, Yun-Sang; Lee, Dong Soo; Chung, June-Key; Jeong, Jae Min.

Afiliação

Moon SH; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Department of Radiology, Gordon Center for Medical Imaging, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Hong MK; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic of Korea.
Kim YJ; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic
Lee YS; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic of Korea.
Lee DS; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic of Korea.
Chung JK; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic
Jeong JM; Department of Nuclear Medicine, Institute of Radiation Medicine, Seoul National University College of Medicine, Republic of Korea; Cancer Research Institute, Seoul National University College of Medicine, Republic of Korea; Department of Nuclear Medicine, Seoul National University Hospital, Republic

Bioorg Med Chem ; 26(9): 2501-2507, 2018 05 15.

Article em En | MEDLINE | ID: mdl-29655611

Assuntos

Glutamato Carboxipeptidase II/metabolismo; Glutamatos/farmacologia; Compostos Heterocíclicos com 1 Anel/farmacologia; Lisina/análogos & derivados; Glicoproteínas de Membrana/metabolismo; Compostos Radiofarmacêuticos/farmacologia; Ureia/análogos & derivados; Animais; Linhagem Celular Tumoral; Estabilidade de Medicamentos; Radioisótopos de Gálio; Glutamatos/síntese química; Glutamatos/química; Glutamatos/metabolismo; Compostos Heterocíclicos com 1 Anel/síntese química; Compostos Heterocíclicos com 1 Anel/química; Compostos Heterocíclicos com 1 Anel/metabolismo; Humanos; Lisina/síntese química; Lisina/metabolismo; Lisina/farmacologia; Masculino; Camundongos Endogâmicos BALB C; Camundongos Nus; Tomografia por Emissão de Pósitrons/métodos; Neoplasias da Próstata/diagnóstico por imagem; Neoplasias da Próstata/metabolismo; Compostos Radiofarmacêuticos/síntese química; Compostos Radiofarmacêuticos/química; Compostos Radiofarmacêuticos/metabolismo; Distribuição Tecidual; Ureia/síntese química; Ureia/metabolismo; Ureia/farmacologia

Palavras-chave

DOTA-GUL; Gallium; Imaging probe; NOTA-GUL; PET; PSMA

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Ureia / Glicoproteínas de Membrana / Compostos Radiofarmacêuticos / Glutamato Carboxipeptidase II / Glutamatos / Compostos Heterocíclicos com 1 Anel / Lisina Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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