Synthesis, Characterization, and Initial Biological Evaluation of [<sup>99m</sup> Tc]Tc-Tricarbonyl-labeled DPA-&#945;-MSH Peptide Derivatives for Potential Melanoma Imaging.

Gao, Feng; Sihver, Wiebke; Bergmann, Ralf; Belter, Birgit; Bolzati, Cristina; Salvarese, Nicola; Steinbach, Jörg; Pietzsch, Jens; Pietzsch, Hans-Jürgen

Synthesis, Characterization, and Initial Biological Evaluation of [^99m Tc]Tc-Tricarbonyl-labeled DPA-α-MSH Peptide Derivatives for Potential Melanoma Imaging.

Gao, Feng; Sihver, Wiebke; Bergmann, Ralf; Belter, Birgit; Bolzati, Cristina; Salvarese, Nicola; Steinbach, Jörg; Pietzsch, Jens; Pietzsch, Hans-Jürgen.

Afiliação

Gao F; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.
Sihver W; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.
Bergmann R; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.
Belter B; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.
Bolzati C; Institute of Condensed Matter Chemistry and Technologies for Energy-ICMATE-CNR, 35127, Padova, Italy.
Salvarese N; Institute of Condensed Matter Chemistry and Technologies for Energy-ICMATE-CNR, 35127, Padova, Italy.
Steinbach J; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.
Pietzsch J; Department of Chemistry and Food Chemistry, School of Science, Technische Universität Dresden, 01062, Dresden, Germany.
Pietzsch HJ; Institute of Radiopharmaceutical Cancer Research, Helmholtz-Zentrum Dresden-Rossendorf, 01328, Dresden, Germany.

ChemMedChem ; 13(11): 1146-1158, 2018 06 06.

Article em En | MEDLINE | ID: mdl-29659163

Assuntos

Melanoma/diagnóstico por imagem; Compostos de Organotecnécio/farmacologia; Piridinas/farmacologia; Compostos Radiofarmacêuticos/farmacologia; alfa-MSH/análogos & derivados; alfa-MSH/farmacologia; Animais; Linhagem Celular Tumoral; Estabilidade de Medicamentos; Humanos; Masculino; Camundongos; Compostos de Organotecnécio/síntese química; Compostos de Organotecnécio/metabolismo; Piridinas/síntese química; Piridinas/metabolismo; Compostos Radiofarmacêuticos/síntese química; Compostos Radiofarmacêuticos/metabolismo; Ratos Wistar; Tecnécio/química; Distribuição Tecidual; alfa-MSH/síntese química; alfa-MSH/metabolismo

Palavras-chave

[99mTc]Tc-tricarbonyl labeling; melanocortin-1 receptor; peptides; radiopharmaceuticals; α-MSH analogues

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piridinas / Alfa-MSH / Compostos de Organotecnécio / Compostos Radiofarmacêuticos / Melanoma Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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