[125I-BH-8-MeO-N-PAT, a new ligand for the study of 5-HT1A receptors in the central nervous system]. / 125I-BH-8-MeO-N-PAT, un nouveau ligand pour l'étude des récepteurs 5-HT1A dans le système nerveux central.
C R Acad Sci III
; 306(4): 147-52, 1988.
Article
em Fr
| MEDLINE
| ID: mdl-2965963
ABSTRACT
Specific radioactive ligands are needed for studying the pharmacological properties and the regional distribution of the different classes of 5-HT1 receptors within the central nervous system. We describe here the synthesis and some characteristics of the first iodinated specific ligand of 5-HT1A receptors. Like its parent compound, the agonist 8-hydroxy-2-(di-n-propylamino)tetralin or 8-OH-DPAT, [125I]-BH-8-MeO-N-PAT, exhibits a high affinity and excellent selectivity for 5-HT1A sites. Its high specific radioactivity makes this ligand a useful tool for studying 5-HT1A receptors in membranes and sections of the rat brain.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tetra-Hidronaftalenos
/
Encéfalo
/
Receptores de Serotonina
/
Naftalenos
Limite:
Animals
Idioma:
Fr
Ano de publicação:
1988
Tipo de documento:
Article