Nonmicrobicidal Small Molecule Inhibition of Polysaccharide Metabolism in Human Gut Microbes: A Potential Therapeutic Avenue.
ACS Chem Biol
; 13(5): 1165-1172, 2018 05 18.
Article
em En
| MEDLINE
| ID: mdl-29660284
ABSTRACT
A new approach for the nonmicrobicidal phenotypic manipulation of prominent gastrointestinal microbes is presented. Low micromolar concentrations of a chemical probe, acarbose, can selectively inhibit the Starch Utilization System and ablate the ability of Bacteroides thetaiotaomicron and B. fragilis strains to metabolize potato starch and pullulan. This strategy has potential therapeutic relevance for the selective modulation of the GI microbiota in a nonmicrobicidal manner.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Amido
/
Bacteroides fragilis
/
Acarbose
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Inibidores de Glicosídeo Hidrolases
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Microbioma Gastrointestinal
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Bacteroides thetaiotaomicron
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Glucanos
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article