Response to Long-term Vitamin D Therapy for Bone Disease in Children With Sickle Cell Disease.
J Pediatr Hematol Oncol
; 40(6): 458-461, 2018 08.
Article
em En
| MEDLINE
| ID: mdl-29668535
ABSTRACT
Patients with sickle cell disease (SCD) are at risk for bone fragility from multiple factors including vitamin D deficiency. To date, no studies have evaluated the efficacy and safety of long-term vitamin D therapy for bone disease in children with SCD. We report a cohort of 4 children with SCD found to have severe vitamin D deficiency, secondary hyperparathyroidism, and abnormal bone mineral density treated with monthly high-dose oral cholecalciferol over 2 years. All patients exhibited a positive response to therapy without hypervitaminosis D or hypercalcemia. Further studies are needed to standardize guidelines for optimal vitamin D dosing and prevention of toxicity.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Deficiência de Vitamina D
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Doenças Ósseas
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Densidade Óssea
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Colecalciferol
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Anemia Falciforme
Tipo de estudo:
Etiology_studies
/
Guideline
Limite:
Adolescent
/
Child
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Female
/
Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article