Increased number of CD4 cells able to bind to natural killer cell targets in the peripheral blood of AIDS related complex patients.
Eur J Cancer Clin Oncol
; 24(3): 369-76, 1988 Mar.
Article
em En
| MEDLINE
| ID: mdl-2968260
ABSTRACT
CD4 cells forming conjugates with natural killer target cells (K562 cells) were measured in the peripheral blood of anti-HIV antibody positive AIDS related complex (ARC) patients and in three control groups (asymptomatic individuals at risk, normal healthy people and patients with acute hepatitis B). These CD4 cells, which are unable to kill K562 cells, were significantly increased in ARC patients as compared to the control groups. Our data indicate that classical CD4 cells are partially replaced, in ARC patients, by a population of natural killer-target binding granular CD4 lymphocytes, and suggest that the functional abnormalities of helper T cells in these patients may be in part a consequence of the relative predominance of these non IL-2 and BCGF producing cells within the circulating CD4 population.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Células Matadoras Naturais
/
Complexo Relacionado com a AIDS
/
Linfócitos T Auxiliares-Indutores
Limite:
Humans
/
Male
Idioma:
En
Ano de publicação:
1988
Tipo de documento:
Article