Multifocal cysts and incidence of pancreatic cancer concomitant with intraductal papillary mucinous neoplasm.
Pancreatology
; 18(4): 399-406, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29685673
ABSTRACT
OBJECTIVES:
The present study was conducted in order to elucidate the relationship between the number of cyst-existing regions and incidence of pancreatic ductal adenocarcinoma (PDAC) concomitant with intraductal papillary mucinous neoplasm (IPMN), which currently remains unclear.METHODS:
Subjects comprised 141 patients undergoing resection for IPMN (Non-invasive IPMN (IPMN with low-to high-grade dysplasia) Nâ¯=â¯94, invasive IPMN Nâ¯=â¯31, and PDAC concomitant with IPMN Nâ¯=â¯16) between November 2000 and February 2017. A logistic regression analysis was performed to assess the relationship between the number of cyst-existing regions (one region/two or more regions) and incidence of PDAC concomitant with IPMN, adjusted by clinical characteristics. Cyst-existing regions were defined by the number of anatomical parts of the pancreas the head/body/tail of the pancreas.RESULTS:
Multiple cyst-existing regions (two or more regions) correlated with the incidence of PDAC concomitant with IPMN (PDAC concomitant with IPMN in one region vs. two or more regions 3/66 vs. 13/75, multivariable odds ratio [OR]â¯=â¯4.11, 95% confidence interval [CI]â¯=â¯1.22 to 18.8, Pâ¯=â¯0.02). In contrast, multiple cyst-existing regions did not correlate with the incidence of IPMN (invasive IPMN in one region vs. two or more regions 13/66 vs. 18/75, ORâ¯=â¯1.19, 95% CIâ¯=â¯0.52 to 2.76, Pâ¯=â¯0.67).CONCLUSIONS:
Multifocal cysts correlated with the incidence of PDAC concomitant with IPMN, and may be a high-risk factor for PDAC concomitant with IPMN.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cisto Pancreático
/
Neoplasias Pancreáticas
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Adenocarcinoma Mucinoso
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Carcinoma Ductal Pancreático
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
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Female
/
Humans
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Male
/
Middle aged
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article