Synthesis and Antimicrobial Study of Novel 1-Benzylated Water-Soluble Isatin-3-hydrazones.
Chem Biodivers
; 15(6): e1800088, 2018 Jun.
Article
em En
| MEDLINE
| ID: mdl-29687663
ABSTRACT
A high-yield synthesis of some novel isatin-3-acylhydrazones on the base of 5-ethylisatin derivatives and Girard's reagent T is described. Antimicrobial activity preliminary SAR study of both 1-benzylated isatins and water-soluble hydrazones was established. The most active against Staphylococcus aureus and Bacillus cereus are ammonium salts bearing 3,4-dichloro- or 4-CF3 substituents in benzyl fragment.
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Texto completo:
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Staphylococcus aureus
/
Bacillus cereus
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Água
/
Hidrazonas
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Isatina
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Antibacterianos
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article