Tranilast Blunts the Hypertrophic and Fibrotic Response to Increased Afterload Independent of Cardiomyocyte Transient Receptor Potential Vanilloid 2 Channels.

Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack

Koch, Sheryl E; Nieman, Michelle L; Robbins, Nathan; Slone, Samuel; Worley, Mariah; Green, Lisa C; Chen, Yamei; Barlow, Alexandria; Tranter, Michael; Wang, HongSheng; Lorenz, John N; Rubinstein, Jack.

Afiliação

Koch SE; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
Nieman ML; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Robbins N; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
Slone S; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Worley M; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
Green LC; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Chen Y; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Barlow A; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
Tranter M; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.
Wang H; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Lorenz JN; Department of Pharmacology & Systems Physiology, University of Cincinnati College of Medicine, Cincinnati, OH.
Rubinstein J; Division of Cardiovascular Health & Disease, Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, OH.

J Cardiovasc Pharmacol ; 72(1): 40-48, 2018 07.

Article em En | MEDLINE | ID: mdl-29688911

Assuntos

Hipertrofia Ventricular Esquerda/prevenção & controle; Miócitos Cardíacos/efeitos dos fármacos; Canais de Cátion TRPV/antagonistas & inibidores; Disfunção Ventricular Esquerda/prevenção & controle; Função Ventricular Esquerda/efeitos dos fármacos; Remodelação Ventricular/efeitos dos fármacos; ortoaminobenzoatos/farmacologia; Animais; Canais de Cálcio/genética; Canais de Cálcio/metabolismo; Modelos Animais de Doenças; Progressão da Doença; Fibrose; Hipertrofia Ventricular Esquerda/metabolismo; Hipertrofia Ventricular Esquerda/patologia; Hipertrofia Ventricular Esquerda/fisiopatologia; Masculino; Camundongos Knockout; Miócitos Cardíacos/metabolismo; Miócitos Cardíacos/patologia; Recuperação de Função Fisiológica; Transdução de Sinais/efeitos dos fármacos; Canais de Cátion TRPV/genética; Canais de Cátion TRPV/metabolismo; Fatores de Tempo; Fator de Crescimento Transformador beta1/metabolismo; Disfunção Ventricular Esquerda/metabolismo; Disfunção Ventricular Esquerda/fisiopatologia; ortoaminobenzoatos/toxicidade

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Função Ventricular Esquerda / Hipertrofia Ventricular Esquerda / Disfunção Ventricular Esquerda / Remodelação Ventricular / Miócitos Cardíacos / Canais de Cátion TRPV / Ortoaminobenzoatos Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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