Prognostic value of Ki67: comparison of the proliferation index between meningiomas with and without infiltration of glial tissue.
Tunis Med
; 95(7): 466-470, 2017 Jul.
Article
em En
| MEDLINE
| ID: mdl-29694649
ABSTRACT
BACKGROUND:
Although generally considered benign, meningiomas can cause significant morbidity and mortality. Histologic grade is the most useful morphologic predictor of recurrence.OBJECTIVES:
To compare Ki67 labeling index between meningioma grade I and meningioma grade II with brain invasion.METHODS:
We analyzed 20 primary meningioma, 10 of which were grade I and 10 of which were grade II. Ki67 proliferative indices were determined in all cases.RESULTS:
The patient population consisted of 9 males and 11 females with mean age of 60 years. For meningioma grade I, the Ki67 labeling index varied between 1 and 15% with an average of 3.1%. A diagnosis of gradeII meningiomas was made solely on the basis of brain invasion. The immunohistochemical study noted that the Ki67 index varied between 1 and 20% with an average of 6,8%.CONCLUSION:
The Ki67 labeling index shows a significant increase from grade I to grade II. It may provide useful prognostic information.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Prognóstico
/
Neoplasias Encefálicas
/
Neuroglia
/
Antígeno Ki-67
/
Proliferação de Células
/
Meningioma
Tipo de estudo:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article