Regulation mechanisms and implications of sperm membrane hyperpolarization.
Mech Dev
; 154: 33-43, 2018 12.
Article
em En
| MEDLINE
| ID: mdl-29694849
ABSTRACT
Mammalian sperm are unable to fertilize the egg immediately after ejaculation. In order to gain fertilization competence, they need to undergo a series of biochemical and physiological modifications inside the female reproductive tract, known as capacitation. Capacitation correlates with two essential events for fertilization hyperactivation, an asymmetric and vigorous flagellar motility, and the ability to undergo the acrosome reaction. At a molecular level, capacitation is associated to phosphorylation cascades, modification of membrane lipids, alkalinization of the intracellular pH, increase in the intracellular Ca2+ concentration and hyperpolarization of the sperm plasma membrane potential. Hyperpolarization is a crucial event in capacitation since it primes the sperm to undergo the exocytosis of the acrosome content, essential to achieve fertilization of the oocyte.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espermatozoides
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Membrana Celular
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Potenciais da Membrana
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article