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Gamma Knife Stereotactic Radiosurgery for the Treatment of Brain Metastases from Primary Tumors of the Urinary Bladder.
Taylor, James M; McTyre, Emory R; Tatter, Stephen B; Laxton, Adrian W; Munley, Michael T; Chan, Michael D; Cramer, Christina K.
Afiliação
  • Taylor JM; Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • McTyre ER; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Tatter SB; Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Laxton AW; Department of Neurosurgery, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Munley MT; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Chan MD; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
  • Cramer CK; Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, North Carolina, USA.
Stereotact Funct Neurosurg ; 96(2): 108-112, 2018.
Article em En | MEDLINE | ID: mdl-29698968
BACKGROUND/AIMS: Brain metastases from bladder cancer are rare and published outcomes data are sparse. To date, no institutions have reported a series of patients with brain metastases from bladder cancer treated with stereotactic radiosurgery (SRS). Our aim was to identify patients with brain metastases from bladder primaries treated with SRS with or without surgical resection and report the clinical outcomes. METHODS: Patients meeting eligibility criteria at our institution between 2000 and 2017 were included. The clinical variables of interest, including overall survival (OS), local recurrence, V12, distant brain failure (DBF), and initial brain metastases velocity, were calculated. Cox proportional hazards analysis was performed to identify predictors of time-to-event outcomes. RESULTS: A total of 14 patients were included. The median OS from the time of treatment was 2.1 months. Factors predictive of OS include intracranial resection (HR 0.21, p = 0.03). The cumulative incidence of local failure was 21% at 6 months and 30% at 12 months. The cumulative incidence of DBF at 6 and 12 months was 23 and 31%, respectively. CONCLUSIONS: The prognosis in this patient population remains guarded. Factors associated with improved survival include intracranial resection. Future, prospective work is needed to further define optimal management.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Neoplasias Encefálicas / Radiocirurgia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Neoplasias da Bexiga Urinária / Neoplasias Encefálicas / Radiocirurgia Tipo de estudo: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article