Vascular endothelial growth factor improves the cognitive decline of Alzheimer's disease via concurrently inducing the expression of ADAM10 and reducing the expression of ß-site APP cleaving enzyme 1 in Tg2576 mice.

Guo, Hongwei; Xia, Deyu; Liao, Shaohua; Niu, Bing; Tang, Jigang; Hu, Huaiqiang; Qian, Hairong; Cao, Bingzhen

Guo, Hongwei; Xia, Deyu; Liao, Shaohua; Niu, Bing; Tang, Jigang; Hu, Huaiqiang; Qian, Hairong; Cao, Bingzhen.

Afiliação

Guo H; Department of Neurology, Jinan Clinical Medicine College of The Second Military Medical University, Jinan, 250000, China; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China.
Xia D; Department of Neurology, Navy General Hospital of Chinese PLA, Beijing, 100048, China.
Liao S; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China.
Niu B; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China.
Tang J; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China.
Hu H; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China.
Qian H; Department of Neurology, Navy General Hospital of Chinese PLA, Beijing, 100048, China. Electronic address: bjqhr@hotmail.com.
Cao B; Department of Neurology, Jinan Clinical Medicine College of The Second Military Medical University, Jinan, 250000, China; Department of Neurology, Jinan Military General Hospital, Jinan, 250000, China. Electronic address: cbzxia2011@163.com.

Neurosci Res ; 142: 49-57, 2019 May.

Article em En | MEDLINE | ID: mdl-29702127

Assuntos

Proteína ADAM10/metabolismo; Doença de Alzheimer/metabolismo; Doença de Alzheimer/psicologia; Secretases da Proteína Precursora do Amiloide/metabolismo; Ácido Aspártico Endopeptidases/metabolismo; Encéfalo/metabolismo; Proteínas de Membrana/metabolismo; Fator A de Crescimento do Endotélio Vascular/metabolismo; Peptídeos beta-Amiloides/metabolismo; Animais; Encéfalo/efeitos dos fármacos; Modelos Animais de Doenças; Regulação para Baixo; Aprendizagem em Labirinto/efeitos dos fármacos; Camundongos Endogâmicos C57BL; Camundongos Transgênicos; Fator A de Crescimento do Endotélio Vascular/administração & dosagem

Palavras-chave

ADAM10; Alzheimer's disease; BACE1; Vascular endothelial growth factor; ß-amyloid protein

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Encéfalo / Ácido Aspártico Endopeptidases / Fator A de Crescimento do Endotélio Vascular / Secretases da Proteína Precursora do Amiloide / Doença de Alzheimer / Proteína ADAM10 / Proteínas de Membrana Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2019 Tipo de documento: Article

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