Farnesyltransferase Inhibition Exacerbates Eosinophilic Inflammation and Airway Hyperreactivity in Mice with Experimental Asthma: The Complex Roles of Ras GTPase and Farnesylpyrophosphate in Type 2 Allergic Inflammation.

Bratt, Jennifer M; Chang, Kevin Y; Rabowsky, Michelle; Franzi, Lisa M; Ott, Sean P; Filosto, Simone; Goldkorn, Tzipora; Arif, Muhammad; Last, Jerold A; Kenyon, Nicholas J; Zeki, Amir A

Bratt, Jennifer M; Chang, Kevin Y; Rabowsky, Michelle; Franzi, Lisa M; Ott, Sean P; Filosto, Simone; Goldkorn, Tzipora; Arif, Muhammad; Last, Jerold A; Kenyon, Nicholas J; Zeki, Amir A.

Afiliação

Bratt JM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Chang KY; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Rabowsky M; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Franzi LM; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Ott SP; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Filosto S; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Goldkorn T; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Arif M; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Last JA; Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, University of California, Davis, Davis, CA 95817.
Kenyon NJ; Department of Internal Medicine, Center for Comparative Respiratory Biology and Medicine, University of California, Davis, Davis, CA 95817; and.
Zeki AA; Department of Internal Medicine, Respiratory Signal Transduction, Genome and Biomedical Sciences Facility, University of California, Davis, Davis, CA 95616.

J Immunol ; 200(11): 3840-3856, 2018 06 01.

Article em En | MEDLINE | ID: mdl-29703864

Assuntos

Asma/tratamento farmacológico; Hiper-Reatividade Brônquica/tratamento farmacológico; Eosinófilos/efeitos dos fármacos; Farnesiltranstransferase/antagonistas & inibidores; Inflamação/tratamento farmacológico; Fosfatos de Poli-Isoprenil/metabolismo; Sesquiterpenos/metabolismo; Proteínas ras/metabolismo; Animais; Asma/metabolismo; Brônquios/efeitos dos fármacos; Brônquios/metabolismo; Hiper-Reatividade Brônquica/metabolismo; Modelos Animais de Doenças; Inibidores Enzimáticos/farmacologia; Eosinófilos/metabolismo; Células Epiteliais/efeitos dos fármacos; Células Epiteliais/metabolismo; Farnesiltranstransferase/metabolismo; Humanos; Inflamação/metabolismo; Pulmão/efeitos dos fármacos; Pulmão/metabolismo; Masculino; Metionina/análogos & derivados; Metionina/farmacologia; Camundongos; Camundongos Endogâmicos BALB C; Ovalbumina/farmacologia; Transdução de Sinais/efeitos dos fármacos

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Fosfatos de Poli-Isoprenil / Asma / Sesquiterpenos / Hiper-Reatividade Brônquica / Proteínas ras / Eosinófilos / Farnesiltranstransferase / Inflamação Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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