Serotonergic Signaling Controls Input-Specific Synaptic Plasticity at Striatal Circuits.
Neuron
; 98(4): 801-816.e7, 2018 05 16.
Article
em En
| MEDLINE
| ID: mdl-29706583
ABSTRACT
Monoaminergic modulation of cortical and thalamic inputs to the dorsal striatum (DS) is crucial for reward-based learning and action control. While dopamine has been extensively investigated in this context, the synaptic effects of serotonin (5-HT) have been largely unexplored. Here, we investigated how serotonergic signaling affects associative plasticity at glutamatergic synapses on the striatal projection neurons of the direct pathway (dSPNs). Combining chemogenetic and optogenetic approaches reveals that impeding serotonergic signaling preferentially gates spike-timing-dependent long-term depression (t-LTD) at thalamostriatal synapses. This t-LTD requires dampened activity of the 5-HT4 receptor subtype, which we demonstrate controls dendritic Ca2+ signals by regulating BK channel activity, and which preferentially localizes at the dendritic shaft. The synaptic effects of 5-HT signaling at thalamostriatal inputs provide insights into how changes in serotonergic levels associated with behavioral states or pathology affect striatal-dependent processes.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tálamo
/
Serotonina
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Corpo Estriado
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Receptores 5-HT4 de Serotonina
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Plasticidade Neuronal
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article