Prostaglandin E2 and IL-23 interconnects STAT3 and RoRÎ³ pathways to initiate Th17 CD4<sup>+</sup> T-cell development during rheumatoid arthritis.

Samuels, Janaiya S; Holland, Lauren; López, María; Meyers, Keya; Cumbie, William G; McClain, Anna; Ignatowicz, Aleksandra; Nelson, Daryllynn; Shashidharamurthy, Rangaiah

Prostaglandin E2 and IL-23 interconnects STAT3 and RoRÎ³ pathways to initiate Th17 CD4⁺ T-cell development during rheumatoid arthritis.

Samuels, Janaiya S; Holland, Lauren; López, María; Meyers, Keya; Cumbie, William G; McClain, Anna; Ignatowicz, Aleksandra; Nelson, Daryllynn; Shashidharamurthy, Rangaiah.

Afiliação

Samuels JS; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Holland L; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
López M; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Meyers K; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Cumbie WG; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
McClain A; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Ignatowicz A; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Nelson D; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA.
Shashidharamurthy R; Department of Pharmaceutical Sciences, School of Pharmacy, Philadelphia College of Osteopathic Medicine-Georgia Campus, Room 3031, 625 Old Peachtree Road, NW, Suwanee, GA, 30024, USA. rangaiahsh@pcom.edu.

Inflamm Res ; 67(7): 589-596, 2018 Jul.

Article em En | MEDLINE | ID: mdl-29713730

Assuntos

Artrite Reumatoide/metabolismo; Citocinas/metabolismo; Dinoprostona/metabolismo; Células Th17/metabolismo; Animais; Antirreumáticos/uso terapêutico; Artrite Reumatoide/tratamento farmacológico; Humanos; Membro 3 do Grupo F da Subfamília 1 de Receptores Nucleares/metabolismo; Fator de Transcrição STAT3/metabolismo; Transdução de Sinais

Palavras-chave

Autoinflammation; Bone erosion; IL-17; IL-23; Prostaglandin E2; RANKL; Rheumatoid arthritis; STAT3 and RoRÎ³; Th17

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Dinoprostona / Citocinas / Células Th17 Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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