Synthesis, characterization and SAR of novel Bezimidazole derivatives as Nematicidal agents.
Pak J Pharm Sci
; 31(3): 827-833, 2018 May.
Article
em En
| MEDLINE
| ID: mdl-29716862
ABSTRACT
Six novel analogues were prepared by reacting benzimidazole molecules (BM and CMB) propiophenone and benzoyl chlorides respectively. The structures of newly synthesized compounds were determined with the help of spectroscopic techniques. The compounds were subjected to in-vitro screening for their activity against nematodes. It was observed that the benzimidazole (BM) derivatives possessed more nematicidal activity as compared to that of cyanomethyl-benzimidazole (CMB) for Meloidogyne incognita. Among them, the propiophenone substituted benzimidazole derivative B3 was found to be the most active compound and can be further studied as lead molecule for development of anthelmintic drugs.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tylenchoidea
/
Benzimidazóis
/
Anti-Helmínticos
/
Antinematódeos
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article