Brain-Derived Neurotrophic Factor as a Treatment Option for Retinal Degeneration.

Daly, Conor; Ward, Rebecca; Reynolds, Alison L; Galvin, Orla; Collery, Ross F; Kennedy, Breandán N

Daly, Conor; Ward, Rebecca; Reynolds, Alison L; Galvin, Orla; Collery, Ross F; Kennedy, Breandán N.

Afiliação

Daly C; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Ireland.
Ward R; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Ireland.
Reynolds AL; School of Veterinary Medicine, University College Dublin, Belfield, Ireland.
Galvin O; School of Biomolecular and Biomedical Science, University College Dublin, Belfield, Ireland.
Collery RF; RenaSci Limited, BioCity, Nottingham, UK.
Kennedy BN; Department of Ophthalmology and Visual Sciences, Eye Institute, Medical College of Wisconsin, Milwaukee, WI, USA.

Adv Exp Med Biol ; 1074: 465-471, 2018.

Article em En | MEDLINE | ID: mdl-29721977

ABSTRACT

ABSTRACT

This review discusses the therapeutic potential of brain-derived neurotrophic factor (BDNF) for retinal degeneration. BDNF, nerve growth factor (NGF), neurotrophin 3 (NT-3) and NT-4/NT-5 belong to the neurotrophin family. These neuronal modulators activate a common receptor and a specific tropomyosin-related kinase (Trk) receptor. BDNF was identified as a photoreceptor protectant in models of retinal degeneration as early as 1992. However, development of effective therapeutics that exploit this pathway has been difficult due to challenges in sustaining therapeutic levels in the retina.

Assuntos

Fator Neurotrófico Derivado do Encéfalo/uso terapêutico; Fármacos Neuroprotetores/uso terapêutico; Degeneração Retiniana/tratamento farmacológico; Animais; Fator Neurotrófico Derivado do Encéfalo/genética; Fator Neurotrófico Derivado do Encéfalo/farmacocinética; Sobrevivência Celular/efeitos dos fármacos; Dependovirus/genética; Modelos Animais de Doenças; Avaliação Pré-Clínica de Medicamentos; Terapia Genética; Vetores Genéticos/uso terapêutico; Humanos; Camundongos; Fármacos Neuroprotetores/farmacocinética; Células Fotorreceptoras de Vertebrados/efeitos dos fármacos; Ratos; Proteínas Recombinantes/farmacocinética; Proteínas Recombinantes/uso terapêutico; Degeneração Retiniana/prevenção & controle; Degeneração Retiniana/terapia

Palavras-chave

BDNF; Brain-Derived Neurotrophic Factor; Neuroprotection; Photoreceptor; Retinal degeneration

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Degeneração Retiniana / Fármacos Neuroprotetores / Fator Neurotrófico Derivado do Encéfalo Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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