Opposite Roles of MerTK Ligands Gas6 and Protein S During Retinal Phagocytosis.
Adv Exp Med Biol
; 1074: 577-583, 2018.
Article
em En
| MEDLINE
| ID: mdl-29721990
ABSTRACT
MerTK is required for photoreceptor outer segment (POS) phagocytosis by retinal pigment epithelial (RPE) cells, a diurnal function essential for vision maintenance. In vivo, MerTK is stimulated at the time of the phagocytic peak through an intracellular signaling pathway. However, MerTK ligands Gas6 and Protein S are expressed in both RPE cells and photoreceptors, and at least one of them required for phagocytosis to occur. Still, their exact role in the retina was not clear until recently. This review combines results from different studies to shed the light on a tissue-specific regulation of MerTK function by its ligands. Indeed, with opposite effects on RPE phagocytosis and changes in their expression levels around the time of POS uptake, Gas6 and Protein S may contribute to the tight control of the acute phagocytic peak in the retina.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fagocitose
/
Retina
/
Proteína S
/
Apoptose
/
Peptídeos e Proteínas de Sinalização Intercelular
/
Proteínas do Olho
/
C-Mer Tirosina Quinase
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article