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Which cytochrome P450 metabolizes phenazepam? Step by step in silico, in vitro, and in vivo studies.
Ivashchenko, Dmitriy V; Rudik, Anastasia V; Poloznikov, Andrey A; Nikulin, Sergey V; Smirnov, Valeriy V; Tonevitsky, Alexander G; Bryun, Eugeniy A; Sychev, Dmitriy A.
Afiliação
  • Ivashchenko DV; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
  • Rudik AV; Institute of Biomedical Chemistry, 10 bldg., Moscow, Russian Federation.
  • Poloznikov AA; Moscow Institute of Physics and Technology, 9 Institutsky lane, 141700, Dolgoprudny, Russian Federation;National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Koroleva, 4, 249036 Obninsk, Russian Federation;SRC "Bioclinicum", Moscow, Russian Federation.
  • Nikulin SV; Moscow Institute of Physics and Technology, 9 Institutsky lane, 141700, Dolgoprudny, Russian Federation;National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Koroleva, 4, 249036 Obninsk, Russian Federation;SRC "Bioclinicum", Moscow, Russian Federation.
  • Smirnov VV; National Research Center - Institute of Immunology Federal Medical-Biological Agency of Russia, Moscow, Russian Federation.
  • Tonevitsky AG; I.M. Sechenov First Moscow State Medical University, Moscow, Russian Federation.
  • Bryun EA; Moscow Institute of Physics and Technology, 9 Institutsky lane, 141700, Dolgoprudny, Russian Federation;National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Koroleva, 4, 249036 Obninsk, Russian Federation;SRC "Bioclinicum", Moscow, Russian Federation.
  • Sychev DA; Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation.
Drug Metab Pers Ther ; 33(2): 65-73, 2018 06 27.
Article em En | MEDLINE | ID: mdl-29727298
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzodiazepinas / Simulação por Computador / Hepatócitos / Citocromo P-450 CYP3A / Hipnóticos e Sedativos / Fígado / Modelos Biológicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Benzodiazepinas / Simulação por Computador / Hepatócitos / Citocromo P-450 CYP3A / Hipnóticos e Sedativos / Fígado / Modelos Biológicos Limite: Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article