Engineered 3-Ketosteroid 9&#945;-Hydroxylases in Mycobacterium neoaurum: an Efficient Platform for Production of Steroid Drugs.

Liu, Hao-Hao; Xu, Li-Qin; Yao, Kang; Xiong, Liang-Bin; Tao, Xin-Yi; Liu, Min; Wang, Feng-Qing; Wei, Dong-Zhi

Engineered 3-Ketosteroid 9α-Hydroxylases in Mycobacterium neoaurum: an Efficient Platform for Production of Steroid Drugs.

Liu, Hao-Hao; Xu, Li-Qin; Yao, Kang; Xiong, Liang-Bin; Tao, Xin-Yi; Liu, Min; Wang, Feng-Qing; Wei, Dong-Zhi.

Afiliação

Liu HH; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Xu LQ; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Yao K; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Xiong LB; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Tao XY; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Liu M; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China.
Wang FQ; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China fqwang@ecust.edu.cn dzhwei@ecust.edu.cn.
Wei DZ; State Key Laboratory of Bioreactor Engineering, Newworld Institute of Biotechnology, East China University of Science and Technology, Shanghai, China fqwang@ecust.edu.cn dzhwei@ecust.edu.cn.

Appl Environ Microbiol ; 84(14)2018 07 15.

Article em En | MEDLINE | ID: mdl-29728384

Assuntos

Proteínas de Bactérias/genética; Proteínas de Bactérias/metabolismo; Oxigenases de Função Mista/genética; Mycobacterium/genética; Mycobacterium/metabolismo; Esteroides/metabolismo; Substituição de Aminoácidos; Androstadienos/metabolismo; Biotransformação; Colesterol; Diosgenina/metabolismo; Deleção de Genes; Engenharia Genética/métodos; Redes e Vias Metabólicas/genética; Modelos Moleculares; Mutagênese Sítio-Dirigida; Micobactérias não Tuberculosas/genética; Micobactérias não Tuberculosas/metabolismo; Oxigenases/metabolismo; Fitosteróis/metabolismo; Alinhamento de Sequência; Análise de Sequência de Proteína

Palavras-chave

3-ketosteroid-9α-hydroxylase; 9α-hydroxy-4-androstene-3,17-dione; 9α-hydroxy-4-androstene-3,17-dione (9-OHAD); Mn25795; androst-1,4-diene-3,17-dione; androst-1,4-diene-3,17-dione (ADD); mycobacterium; sterol; sterols

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esteroides / Proteínas de Bactérias / Oxigenases de Função Mista / Mycobacterium Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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