Safety profile of intraoperative methadone for analgesia after major spine surgery: An observational study of 1,478 patients.
J Opioid Manag
; 14(2): 83-87, 2018.
Article
em En
| MEDLINE
| ID: mdl-29733094
ABSTRACT
OBJECTIVE:
To investigate the incidence of perioperative adverse events in patients receiving intravenous methadone for major spine surgery.DESIGN:
Retrospective review of perioperative records from March 2011 and February 2016.SETTING:
University of Virginia Healthsystem. PATIENTS Adult patients undergoing elective spinal fusion of two or more levels. MAIN OUTCOMEMEASURES:
Incidence of respiratory depression, time to extubation, hypotension, hypoxemia, reintubation, cardiac complications, and death.RESULTS:
Reviewed 1,478 patient records. Mean intraoperative methadone dose was 0.14 ± 0.07 mg/kg. A total of 1,142 patients (77.4 percent) were extubated in the operating room, 543 (36.8 percent) experienced respiratory depression, 1,180 (79.8 percent) hypoxemia, and 22 (1.5 percent) required reintubation. Cardiac complications included arrhythmias (289 patients, 29.9 percent), QTc prolongation (568 patients, 58.8 percent), and myocardial infarction (16 patients, 1.1 percent). Two in hospital deaths occurred (0.14 percent).CONCLUSIONS:
Mild-moderate respiratory depression is observed following a one-time dose of intraoperative methadone, and monitoring in an appropriate postoperative setting is recommended.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Dor Pós-Operatória
/
Fusão Vertebral
/
Dor nas Costas
/
Analgésicos Opioides
/
Metadona
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
/
Middle aged
País/Região como assunto:
America do norte
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article