Hepatitis B virus-specific T cell responses after stopping nucleos(t)ide analogue therapy in HBeAg-negative chronic hepatitis B.

Rinker, Franziska; Zimmer, Christine L; Höner Zu Siederdissen, Christoph; Manns, Michael P; Kraft, Anke R M; Wedemeyer, Heiner; Björkström, Niklas K; Cornberg, Markus

Rinker, Franziska; Zimmer, Christine L; Höner Zu Siederdissen, Christoph; Manns, Michael P; Kraft, Anke R M; Wedemeyer, Heiner; Björkström, Niklas K; Cornberg, Markus.

Afiliação

Rinker F; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany.
Zimmer CL; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Höner Zu Siederdissen C; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Manns MP; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), c/o CRC Hannover, Germany.
Kraft ARM; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany.
Wedemeyer H; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany.
Björkström NK; Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Cornberg M; Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany; German Center for Infection Research, Partner Site Hannover-Braunschweig, Germany; Centre for Individualised Infection Medicine (CIIM), c/o CRC Hannover, Germany. Electronic address: Cornberg.Ma

J Hepatol ; 69(3): 584-593, 2018 09.

Article em En | MEDLINE | ID: mdl-29758333

Assuntos

Antígenos de Superfície da Hepatite B/sangue; Antígenos E da Hepatite B/sangue; Vírus da Hepatite B; Hepatite B Crônica; Nucleosídeos/uso terapêutico; Linfócitos T; Suspensão de Tratamento; Adulto; Antivirais/uso terapêutico; DNA Viral/sangue; Feminino; Alemanha; Vírus da Hepatite B/efeitos dos fármacos; Vírus da Hepatite B/fisiologia; Hepatite B Crônica/diagnóstico; Hepatite B Crônica/tratamento farmacológico; Hepatite B Crônica/imunologia; Hepatite B Crônica/virologia; Humanos; Imunidade Celular/efeitos dos fármacos; Masculino; Pessoa de Meia-Idade; Recidiva; Linfócitos T/efeitos dos fármacos; Linfócitos T/imunologia

Palavras-chave

Chronic hepatitis B; Discontinuation of treatment; HBV-specific T cell response; Nucleos(t)ide analogue (NA); PD-L1 blockade; T cell phenotype

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Linfócitos T / Vírus da Hepatite B / Hepatite B Crônica / Suspensão de Tratamento / Antígenos E da Hepatite B / Antígenos de Superfície da Hepatite B / Nucleosídeos Tipo de estudo: Diagnostic_studies / Observational_studies Limite: Adult / Female / Humans / Male / Middle aged País/Região como assunto: Europa Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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