Glycyrrhizin ameliorates inflammatory pain by inhibiting microglial activation-mediated inflammatory response via blockage of the HMGB1-TLR4-NF-kB pathway.

Sun, Xiaojuan; Zeng, Hongyou; Wang, Qingsong; Yu, Qingwen; Wu, Jianxiong; Feng, You; Deng, Peng; Zhang, Hongxing

Sun, Xiaojuan; Zeng, Hongyou; Wang, Qingsong; Yu, Qingwen; Wu, Jianxiong; Feng, You; Deng, Peng; Zhang, Hongxing.

Afiliação

Sun X; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Zeng H; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Wang Q; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Yu Q; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Wu J; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Feng Y; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Deng P; Department of Anesthesiology, the Hospital of Chinese Traditional Medicine of Leshan, Leshan 614000, PR China.
Zhang H; Department of Hand Surgery, Xi'an Jiaotong University Health Science Center, Honghui Hospital, Xi'an 710054, PR China. Electronic address: hongxingzhangedu@163.com.

Exp Cell Res ; 369(1): 112-119, 2018 08 01.

Article em En | MEDLINE | ID: mdl-29763588

Assuntos

Ácido Glicirrízico/farmacologia; Inflamação/prevenção & controle; Microglia/efeitos dos fármacos; Dor/prevenção & controle; Animais; Células Cultivadas; Células HEK293; Proteína HMGB1/metabolismo; Temperatura Alta; Humanos; Hiperalgesia/metabolismo; Hiperalgesia/patologia; Hiperalgesia/prevenção & controle; Inflamação/complicações; Inflamação/metabolismo; Lipopolissacarídeos; Masculino; Camundongos; Camundongos Endogâmicos C57BL; Microglia/metabolismo; NF-kappa B/metabolismo; Dor/etiologia; Dor/metabolismo; Transdução de Sinais/efeitos dos fármacos; Receptor 4 Toll-Like/metabolismo

Palavras-chave

Glycyrrhizin; HMGB1; Inflammation; Inflammatory pain; Microglial activation; TLR4-NF-kB pathway

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Dor / Microglia / Ácido Glicirrízico / Inflamação Tipo de estudo: Etiology_studies / Prognostic_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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