Expressions of H2AX in cervical squamous carcinoma and their clinical significances.

ABSTRACT

OBJECTIVE: To evaluate the expression and clinical significance of H2AX in cervical squamous carcinoma. MATERIALS AND METHODS: The expression of H2AX in the cervical squamous carcinoma of 37 patients and in the normal cervical tissue of 15 patients was detected by immuneohistochemical method. Chi-square, correlation analysis, and Kaplan-Meier were utilized to analyze the data. RESULTS: The positive expression rate of H2AX in cervical squamous carcinoma was higher than that in normal cervical tissues (p = 0.016) . The expression of H2AX was negatively correlated with FIGO staging, vaginal invasion, and parametrial infiltration (p < 0.05). Survival analysis showed the expression intensity of H2AX had no significant effect on the prognosis. CONCLUSION: H2AX was an anticancer protein for cervical squamous carcinoma.