An observational clinical case of Zika virus-associated neurological disease is associated with primary IgG response and enhanced TNF levels.
J Gen Virol
; 99(7): 913-916, 2018 07.
Article
em En
| MEDLINE
| ID: mdl-29771234
ABSTRACT
Descriptive clinical data help to reveal factors that may provoke Zika virus (ZIKV) neuropathology. The case of a 24-year-old female with a ZIKV-associated severe acute neurological disorder was studied. The levels of ZIKV in the cerebrospinal fluid (CSF) were 50 times higher than the levels in other compartments. An acute anti-flavivirus IgG, together with enhanced TNF-alpha levels, may have contributed to ZIKV invasion in the CSF, whereas the unbiased genome sequencing [obtained by next-generation sequencing (NGS)] of the CSF revealed that no virus mutations were associated with the anatomic compartments (CSF, serum, saliva and urine).
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina G
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Fator de Necrose Tumoral alfa
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Inflamação Neurogênica
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Zika virus
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Infecção por Zika virus
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Anticorpos Antivirais
Tipo de estudo:
Risk_factors_studies
Limite:
Adult
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Female
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Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article