New insights into the in vitro biological effects, in silico docking and chemical profile of clary sage - Salvia sclarea L.
Comput Biol Chem
; 75: 111-119, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29772456
ABSTRACT
Salvia sclarea L. is traditionally used to manage common human ailments and is consumed as a food product. This study aimed to establish the phytochemical profile and antioxidant potential of ethyl acetate, methanol, and water extracts of Salvia sclarea. The inhibitory action of the extracts against α-amylase, α-glucosidase, acetylcholinesterase, butyrylcholinesterase, and tyrosinase was also investigated. Methanol extract showed the highest phenolic and flavonoid contents (81.78â¯mg GAE/g extract and 40.59â¯mg RE/g extract, respectively). Reversed phase high performance liquid chromatography with diode array detector analysis revealed that S. sclarea was rich in rosmarinic acid. The water extract exhibited the lowest inhibitory activity against α-amylase but the upmost activity against α-glucosidase (0.19 and 18.24â¯mmol ACAE/g extract, respectively). Experimental data showed that only the water extract (8.86â¯mg KAE/g extract) significantly inhibited tyrosinase. Docking studies showed that quercetin binds to tyrosinase by two hydrogen and a pi-pi bonds. Salvia sclarea showed interesting biological activity against key enzymes involved in the pathogenesis of common ailments.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Extratos Vegetais
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Salvia
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Inibidores Enzimáticos
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Simulação de Acoplamento Molecular
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Compostos Fitoquímicos
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Antioxidantes
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article