Molecular Diversity by Olefin Cross-Metathesis on Solid Support. Generation of Libraries of Biologically Promising ß-Lactam Derivatives.
Molecules
; 23(5)2018 May 16.
Article
em En
| MEDLINE
| ID: mdl-29772720
ABSTRACT
The application of the reagent-based diversification strategy for generation of libraries of biologically promising ß-lactam derivatives is described. Key features are the versatility of the linker used and the cross-metathesis functionalization at the cleavage step. From an immobilized primary library, diversity was expanded by applying different cleavage conditions, leading to a series of cholesterol absorption inhibitor analogues together with interesting hybrid compounds through incorporation of a chalcone moiety.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Beta-Lactamas
/
Alcenos
/
Bibliotecas de Moléculas Pequenas
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article