Precursor-Directed Generation of Indolocarbazoles with Topoisomerase IIα Inhibitory Activity.
Mar Drugs
; 16(5)2018 May 17.
Article
em En
| MEDLINE
| ID: mdl-29772796
ABSTRACT
One new indolocarbazole, 3-hydroxy-K252d (3), together with the recently reported 3-hydroxyholyrine A (1) and 3'-N-acetyl-3-hydroxyholyrine A (2), were obtained by feeding a culture of the marine-derived Streptomyces strain OUCMDZ-3118 with 5-hydroxy-l-tryptophan. Their structures were elucidated on the basis of spectroscopic analysis. Compound 1 potently induced apoptosis of gastric cancer cells by inhibiting topoisomerase IIα enzyme activity and reducing the expression of antiapoptosis protein level. Compound 3 displayed moderate cytotoxicity against the A549 and MCF-7 cell lines with IC50 values of 1.2 ± 0.05 µM, 1.6 ± 0.09 µM, respectively.
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Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Streptomyces
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Carbazóis
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Organismos Aquáticos
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Inibidores da Topoisomerase II
Limite:
Humans
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article