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Kakeromamide A, a new cyclic pentapeptide inducing astrocyte differentiation isolated from the marine cyanobacterium Moorea bouillonii.
Nakamura, Fumiaki; Maejima, Hiroshi; Kawamura, Midori; Arai, Daisuke; Okino, Tatsufumi; Zhao, Meng; Ye, Tao; Lee, Jungyeol; Chang, Young-Tae; Fusetani, Nobuhiro; Nakao, Yoichi.
Afiliação
  • Nakamura F; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
  • Maejima H; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
  • Kawamura M; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
  • Arai D; Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan.
  • Okino T; Graduate School of Environmental Science, Hokkaido University, Sapporo 060-0810, Japan.
  • Zhao M; State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China.
  • Ye T; State Key Laboratory of Chemical Oncogenomics, Peking University Shenzhen Graduate School, Xili, Nanshan District, Shenzhen 518055, China.
  • Lee J; Department of Chemistry, POSTECH, Pohang 37673, Republic of Korea.
  • Chang YT; Department of Chemistry, POSTECH, Pohang 37673, Republic of Korea.
  • Fusetani N; Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan; Fisheries and Oceans Hakodate, 3-1-1 Minato-cho, Hakodate 041-8611, Japan.
  • Nakao Y; Department of Chemistry and Biochemistry, Graduate School of Advanced Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan; Research Institute for Science and Engineering, Waseda University, 3-4-1 Okubo, Shinjuku-ku, Tokyo 169-8555, Japan. Electronic address: a
Bioorg Med Chem Lett ; 28(12): 2206-2209, 2018 07 01.
Article em En | MEDLINE | ID: mdl-29773503
Kakeromamide A (1), a new cyclic pentapeptide encompassing a thiazole ring moiety and a ß-amino acid, was isolated from the marine cyanobacterium Moorea bouillonii. Its structure was elucidated by the spectral analysis and the modified Marfey's method. Compound 1 induced differentiation of neural stem cells into astrocytes at the concentration of 10 µM.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Astrócitos / Cianobactérias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Oligopeptídeos / Astrócitos / Cianobactérias / Antineoplásicos Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article