Influence of sex and pregnancy on survival in patients admitted with heart failure: Data from a prospective multicenter registry.
Clin Cardiol
; 41(7): 924-930, 2018 Jul.
Article
em En
| MEDLINE
| ID: mdl-29774566
ABSTRACT
BACKGROUND:
Female sex is an independent predictor of better survival in patients with heart failure (HF), but the mechanism of this association is unknown. On the other hand, pregnancies have a strong influence on the cardiovascular system.HYPOTHESIS:
Sex and previous gestations might have a prognostic impact on 1-year mortality in patients admitted with HF.METHODS:
We conducted an observational, prospective, consecutive, multicenter registry of 1831 patients (756 females [41.2%]) admitted with HF.RESULTS:
Females had a more advanced age (75.2 ±11.4 vs 70.4 ±12.2 years), less ischemic heart disease (167 [25.3%] vs 446 [47.3%]), and higher left ventricular ejection fraction (52.0% ±16.6% vs 41.1% ±17.0%) than did men (all P values <0.001). During 1-year follow-up, 373 (20.4%) patients died (151 females and 222 males). Female sex was an independent predictor for survival (hazard ratio 0.79, 95% confidence interval 0.64-0.98, P = 0.03). In 504 women (65.9%), the exact number of previous pregnancies could be determined; 62 women (12.3%) had no previous pregnancies, 288 (57.1%) women had 1 or 2 pregnancies, and 154 women (30.6%) had ≥3 pregnancies. We found an association between the number of previous gestations and better survival (hazard ratio 0.878, 95% confidence interval 0.773-0.997, P = 0.045).CONCLUSIONS:
In patients admitted with HF, female sex and the number of previous pregnancies are independently associated with better 1-year survival.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Sistema de Registros
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Medição de Risco
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Insuficiência Cardíaca
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Pacientes Internados
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Limite:
Aged
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Female
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Humans
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Male
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Pregnancy
País/Região como assunto:
Europa
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article