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Large-scale transcriptomic analysis reveals that pridopidine reverses aberrant gene expression and activates neuroprotective pathways in the YAC128 HD mouse.
Kusko, Rebecca; Dreymann, Jennifer; Ross, Jermaine; Cha, Yoonjeong; Escalante-Chong, Renan; Garcia-Miralles, Marta; Tan, Liang Juin; Burczynski, Michael E; Zeskind, Ben; Laifenfeld, Daphna; Pouladi, Mahmoud; Geva, Michal; Grossman, Iris; Hayden, Michael R.
Afiliação
  • Kusko R; Immuneering Corporation, Cambridge, MA, 02142, USA.
  • Dreymann J; Research and Development, Teva Pharmaceutical Industries Ltd, Netanya, Israel.
  • Ross J; Immuneering Corporation, Cambridge, MA, 02142, USA.
  • Cha Y; Immuneering Corporation, Cambridge, MA, 02142, USA.
  • Escalante-Chong R; Immuneering Corporation, Cambridge, MA, 02142, USA.
  • Garcia-Miralles M; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore, 138648, Singapore.
  • Tan LJ; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore, 138648, Singapore.
  • Burczynski ME; Research and Development, Teva Pharmaceutical Industries Ltd, Netanya, Israel.
  • Zeskind B; Immuneering Corporation, Cambridge, MA, 02142, USA.
  • Laifenfeld D; Research and Development, Teva Pharmaceutical Industries Ltd, Netanya, Israel.
  • Pouladi M; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research, Singapore (A*STAR), Singapore, 138648, Singapore.
  • Geva M; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 117597, Singapore.
  • Grossman I; Research and Development, Teva Pharmaceutical Industries Ltd, Netanya, Israel.
  • Hayden MR; Research and Development, Teva Pharmaceutical Industries Ltd, Netanya, Israel.
Mol Neurodegener ; 13(1): 25, 2018 05 21.
Article em En | MEDLINE | ID: mdl-29783994
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Expressão Gênica / Doença de Huntington / Fármacos Neuroprotetores / Neuroproteção Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Piperidinas / Expressão Gênica / Doença de Huntington / Fármacos Neuroprotetores / Neuroproteção Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2018 Tipo de documento: Article