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Correct Laminar Positioning in the Neocortex Influences Proper Dendritic and Synaptic Development.
Martineau, Fanny Sandrine; Sahu, Surajit; Plantier, Vanessa; Buhler, Emmanuelle; Schaller, Fabienne; Fournier, Lauriane; Chazal, Geneviève; Kawasaki, Hiroshi; Represa, Alfonso; Watrin, Françoise; Manent, Jean-Bernard.
Afiliação
  • Martineau FS; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Sahu S; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Plantier V; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Buhler E; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Schaller F; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Fournier L; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Chazal G; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Kawasaki H; Department of Medical Neuroscience, Graduate School of Medical Sciences, Kanazawa University, Ishikawa, Japan.
  • Represa A; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Watrin F; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
  • Manent JB; INMED, Aix-Marseille University, INSERM U901, Marseille, France.
Cereb Cortex ; 28(8): 2976-2990, 2018 08 01.
Article em En | MEDLINE | ID: mdl-29788228
ABSTRACT
The neocortex is a 6-layered laminated structure with a precise anatomical and functional organization ensuring proper function. Laminar positioning of cortical neurons, as determined by termination of neuronal migration, is a key determinant of their ability to assemble into functional circuits. However, the exact contribution of laminar placement to dendrite morphogenesis and synapse formation remains unclear. Here we manipulated the laminar position of cortical neurons by knocking down doublecortin (Dcx), a crucial effector of migration, and show that misplaced neurons fail to properly form dendrites, spines, and functional glutamatergic and GABAergic synapses. We further show that knocking down Dcx in properly positioned neurons induces similar but milder defects, suggesting that the laminar misplacement is the primary cause of altered neuronal development. Thus, the specific laminar environment of their fated layers is crucial for the maturation of cortical neurons, and influences their functional integration into developing cortical circuits.
Assuntos

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Somatossensorial / Sinapses / Dendritos / Neurônios Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Córtex Somatossensorial / Sinapses / Dendritos / Neurônios Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article