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Identifying and avoiding off-target effects of RNase H-dependent antisense oligonucleotides in mice.
Hagedorn, Peter H; Pontoppidan, Malene; Bisgaard, Tina S; Berrera, Marco; Dieckmann, Andreas; Ebeling, Martin; Møller, Marianne R; Hudlebusch, Heidi; Jensen, Marianne L; Hansen, Henrik F; Koch, Troels; Lindow, Morten.
Afiliação
  • Hagedorn PH; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Pontoppidan M; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Bisgaard TS; Department of Biotechnology and Biomedicine, Technical University of Denmark, DK-2800 Kgs. Lyngby, Denmark.
  • Berrera M; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Dieckmann A; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Ebeling M; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Møller MR; Pharmaceutical Sciences, Roche Pharma Research and Early Development, Roche Innovation Center Basel, 4070 Basel, Switzerland.
  • Hudlebusch H; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Jensen ML; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Hansen HF; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Koch T; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
  • Lindow M; Therapeutic Modalities, Roche Pharma Research and Early Development, Roche Innovation Center Copenhagen, DK-2970 Hørsholm, Denmark.
Nucleic Acids Res ; 46(11): 5366-5380, 2018 06 20.
Article em En | MEDLINE | ID: mdl-29790953
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Terapia Genética / Oligonucleotídeos Antissenso / RNA Complementar / Ribonuclease H / Ácidos Nucleicos Heteroduplexes Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: RNA Mensageiro / Terapia Genética / Oligonucleotídeos Antissenso / RNA Complementar / Ribonuclease H / Ácidos Nucleicos Heteroduplexes Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article