Control of Heterologous Simian Immunodeficiency Virus SIV<sub>smE660</sub> Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh, Shakti; Ramírez-Salazar, Eric G; Doueiri, Rami; Valentin, Antonio; Rosati, Margherita; Hu, Xintao; Keele, Brandon F; Shen, Xiaoying; Tomaras, Georgia D; Ferrari, Guido; LaBranche, Celia; Montefiori, David C; Das, Jishnu; Alter, Galit; Trinh, Hung V; Hamlin, Christopher; Rao, Mangala; Dayton, Frances; Bear, Jenifer; Chowdhury, Bhabadeb; Alicea, Candido; Lifson, Jeffrey D; Broderick, Kate E; Sardesai, Niranjan Y; Sivananthan, Sandra J; Fox, Christopher B; Reed, Steven G; Venzon, David J; Hirsch, Vanessa M; Pavlakis, George N; Felber, Barbara K

Control of Heterologous Simian Immunodeficiency Virus SIV_smE660 Infection by DNA and Protein Coimmunization Regimens Combined with Different Toll-Like-Receptor-4-Based Adjuvants in Macaques.

Singh, Shakti; Ramírez-Salazar, Eric G; Doueiri, Rami; Valentin, Antonio; Rosati, Margherita; Hu, Xintao; Keele, Brandon F; Shen, Xiaoying; Tomaras, Georgia D; Ferrari, Guido; LaBranche, Celia; Montefiori, David C; Das, Jishnu; Alter, Galit; Trinh, Hung V; Hamlin, Christopher; Rao, Mangala; Dayton, Frances; Bear, Jenifer; Chowdhury, Bhabadeb; Alicea, Candido; Lifson, Jeffrey D; Broderick, Kate E; Sardesai, Niranjan Y; Sivananthan, Sandra J; Fox, Christopher B; Reed, Steven G; Venzon, David J; Hirsch, Vanessa M; Pavlakis, George N; Felber, Barbara K.

Afiliação

Singh S; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Ramírez-Salazar EG; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Doueiri R; Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Valentin A; Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Rosati M; Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Hu X; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Keele BF; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Shen X; Duke Human Vaccine Institute, Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA.
Tomaras GD; Duke Human Vaccine Institute, Department of Immunology, Duke University Medical Center, Durham, North Carolina, USA.
Ferrari G; Duke Human Vaccine Institute, Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina, USA.
LaBranche C; Duke Human Vaccine Institute, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Montefiori DC; Duke Human Vaccine Institute, Department of Molecular Genetics, Duke University Medical Center, Durham, North Carolina, USA.
Das J; Duke Human Vaccine Institute, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Alter G; Duke Human Vaccine Institute, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Trinh HV; Duke Human Vaccine Institute, Department of Surgery, Duke University Medical Center, Durham, North Carolina, USA.
Hamlin C; Ragon Institute of MGH, MIT, and Harvard University, Cambridge, Massachusetts, USA.
Rao M; Ragon Institute of MGH, MIT, and Harvard University, Cambridge, Massachusetts, USA.
Dayton F; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Bear J; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Chowdhury B; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Alicea C; Henry M. Jackson Foundation for the Advancement of Military Medicine, Bethesda, Maryland, USA.
Lifson JD; U.S. Military HIV Research Program, Walter Reed Army Institute of Research, Silver Spring, Maryland, USA.
Broderick KE; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Sardesai NY; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Sivananthan SJ; Human Retrovirus Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Fox CB; Human Retrovirus Pathogenesis Section, Vaccine Branch, Center for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, USA.
Reed SG; AIDS and Cancer Virus Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, Frederick, Maryland, USA.
Venzon DJ; Inovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania, USA.
Hirsch VM; Inovio Pharmaceuticals, Inc., Plymouth Meeting, Pennsylvania, USA.
Pavlakis GN; Infectious Disease Research Institute, Seattle, Washington, USA.
Felber BK; Infectious Disease Research Institute, Seattle, Washington, USA.

J Virol ; 92(15)2018 08 01.

Article em En | MEDLINE | ID: mdl-29793957

Assuntos

Anticorpos Neutralizantes/imunologia; Anticorpos Antivirais/imunologia; Produtos do Gene env; Imunidade Humoral; Vacinas contra a SAIDS; Síndrome de Imunodeficiência Adquirida dos Símios; Vírus da Imunodeficiência Símia; Vacinas de DNA; Adjuvantes Imunológicos/farmacologia; Substituição de Aminoácidos; Animais; Produtos do Gene env/genética; Produtos do Gene env/imunologia; Produtos do Gene env/farmacologia; Imunização; Macaca; Mutação de Sentido Incorreto; Vacinas contra a SAIDS/genética; Vacinas contra a SAIDS/imunologia; Vacinas contra a SAIDS/farmacologia; Síndrome de Imunodeficiência Adquirida dos Símios/genética; Síndrome de Imunodeficiência Adquirida dos Símios/imunologia; Síndrome de Imunodeficiência Adquirida dos Símios/prevenção & controle; Vírus da Imunodeficiência Símia/genética; Vírus da Imunodeficiência Símia/imunologia; Receptor 4 Toll-Like/agonistas; Receptor 4 Toll-Like/imunologia; Vacinas de DNA/genética; Vacinas de DNA/imunologia; Vacinas de DNA/farmacologia

Palavras-chave

A/K variant; ADCC; ADCD; ADNP; Ab glycosylation structures; DNA; HIV; QS21; SIVmac251; SIVsmE660; SIVsmE660 T/F; T cell responses; TLR4; TLR7; TRIM-5α; V2 responses; acquisition delay; adjuvant; binding antibody; correlate of viremia control; cyclic V2; humoral responses; immunization; linear peptide; mucosal responses; neutralizing antibody; protein; reduced risk of infection; repeated low-dose rectal challenge; rhesus macaque; scaffolded gp70-V1V2; systems serology; vaccination; vaccine; viremia control

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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Produtos do Gene env / Síndrome de Imunodeficiência Adquirida dos Símios / Vírus da Imunodeficiência Símia / Vacinas contra a SAIDS / Vacinas de DNA / Anticorpos Neutralizantes / Imunidade Humoral / Anticorpos Antivirais Limite: Animals Idioma: En Ano de publicação: 2018 Tipo de documento: Article

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