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Analysis of Blood Plasma Protein Composition in Patients with Cerebral Ischemia.
Kisrieva, Yu S; Petushkova, N A; Samenkova, N F; Kuznetsova, G P; Larina, O V; Teryaeva, N B; Zgoda, V G; Karuzina, I I; Usachev, D U; Belyaev, A Yu.
Afiliação
  • Kisrieva YS; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia. juliaks@bk.ru.
  • Petushkova NA; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Samenkova NF; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Kuznetsova GP; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Larina OV; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Teryaeva NB; N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Zgoda VG; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Karuzina II; V. N. Orekhovich Research Institute of Biomedical Chemistry, Moscow, Russia.
  • Usachev DU; N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation, Moscow, Russia.
  • Belyaev AY; N. N. Burdenko National Research and Practical Centre for Neurosurgery, Ministry of Health of the Russian Federation, Moscow, Russia.
Bull Exp Biol Med ; 165(1): 22-26, 2018 May.
Article em En | MEDLINE | ID: mdl-29797129
ABSTRACT
Blood plasma proteome in patients with cerebral ischemia and healthy individuals was studied using comparative proteomic analysis based on tandem HPLC-MS/MS. Mass spectra were analysed in an automated mode using Progenesis LS-MS software and 256 proteins were identified. Significant quantitative differences were revealed for 20 proteins. It was found that changes in the blood plasma proteome in subjects with cerebral ischemia involved a wide range of proteins molecular chaperones, fibrinolysis, angiogenesis, and immune system proteins, proteins involved in homeostasis maintenance, cell differentiation and proliferation, regulators of apoptosis, and cytoskeleton proteins.
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Isquemia Encefálica Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Infarto Cerebral / Isquemia Encefálica Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2018 Tipo de documento: Article