Late-phase human herpesvirus 6B reactivation in hematopoietic stem cell transplant recipients.
Transpl Infect Dis
; 20(4): e12916, 2018 Aug.
Article
em En
| MEDLINE
| ID: mdl-29797616
ABSTRACT
BACKGROUND:
We sought to determine whether late-phase human herpesvirus 6B (HHV-6B) infection in hematopoietic stem cell transplant (HSCT) recipients was associated with serious outcomes and mortality.METHODS:
The occurrence and course of HHV-6B infection was monitored for at least 60 days after transplant using virus isolation and real-time polymerase chain reaction. Risk factors for late-phase HHV-6B infection were examined, and the propensity score was calculated with significant risk factors. The inverse probability-weighted multivariable logistic regression analysis was performed to estimate odds ratios (ORs) and the 95% confidence intervals (95% CI) for mortality.RESULTS:
Late-phase HHV-6B infection was observed in 12/89 (13.5%) of the HSCT recipients. Older age (OR 10.3, 95% CI 2.1/72.9, P = .0027), hematologic malignancy (OR 10.3, 95% CI 1.8/97.1, P = .0063), unrelated donor transplantation (OR 5.3, 95% CI 1.1/36.0, P = .0345), and sex-mismatched donor transplantation (OR 6.3, 95% CI 1.4/39.5, P = .0149) were identified as risk factors for late-phase HHV-6B infection. Fifteen subjects died (17%). Inverse probability-weighted multivariable logistic model analysis revealed that late-phase HHV-6B infection was an independent risk factor for mortality (OR 4.2, 95% CI 1.7/11.0, P = .0012). Among 5 of the fatal cases of late-phase HHV-6B infection, viral infection might be associated with severe clinical manifestations.CONCLUSION:
Late-phase HHV-6B infection in HSCT recipients was associated with worse outcomes. The full spectrum of clinical features of the infection has not been fully elucidated, and therefore, recipients with high-risk factors for late-phase HHV-6B infection should be carefully monitored.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ativação Viral
/
Hospedeiro Imunocomprometido
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Herpesvirus Humano 6
/
Transplante de Células-Tronco Hematopoéticas
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Infecções por Roseolovirus
Tipo de estudo:
Prognostic_studies
/
Risk_factors_studies
Limite:
Child
/
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article