Effect of neuromuscular electrical stimulation frequency on muscles of the tongue.
Muscle Nerve
; 58(3): 441-448, 2018 09.
Article
em En
| MEDLINE
| ID: mdl-29797723
ABSTRACT
INTRODUCTION:
Neuromuscular electrical stimulation (NMES) for the treatment of swallowing disorders is delivered at a variety of stimulation frequencies. We examined the effects of stimulation frequency on tongue muscle plasticity in an aging rat model.METHODS:
Eighty-six young, middle-aged, and old rats were assigned to either bilateral hypoglossal nerve stimulation at 10 or 100 Hz (5 days/week, 8 weeks), sham, or no-implantation conditions. Muscle contractile properties and myosin heavy chain (MyHC) composition were determined for hyoglossus (HG) and styloglossus (SG) muscles.RESULTS:
Eight weeks of 100-Hz stimulation resulted in the greatest changes in muscle contractile function with significantly longer contraction and half-decay times, the greatest reduction in fatigue, and a transition toward slowly contracting, fatigue-resistant MyHC isoforms.DISCUSSION:
NMES at 100-Hz induced considerable changes in contractile and phenotypic profiles of HG and SG muscles, suggesting higher frequency NMES may yield a greater therapeutic effect. Muscle Nerve, 2018.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Língua
/
Fadiga Muscular
/
Nervo Hipoglosso
/
Contração Muscular
Limite:
Animals
Idioma:
En
Ano de publicação:
2018
Tipo de documento:
Article